3-Thiazolidinepropionic acid, 4-oxo-2-thioxo- → HCID 86752508, compound

HRID 1069122Notes

Reaction equation

HRID 1069122 reaction equation
[C:1]([C:5]1[CH:19]=[CH:18][C:8]([O:9][C:10]2[CH:17]=[CH:16][C:13](C=O)=[CH:12][CH:11]=2)=[CH:7][CH:6]=1)([CH3:4])([CH3:3])[CH3:2].[C:20]([O-])(=O)C.[Na+].[C:25]([CH2:28][CH2:29][N:30]1[C:34](=[O:35])[CH2:33][S:32][C:31]1=[S:36])([OH:27])=[O:26]>C(O)(=O)C>[C:1]([C:5]1[CH:6]=[CH:7][C:8]([O:9][C:10]2[CH:17]=[C:16]([CH:20]=[C:33]3[S:32][C:31](=[S:36])[N:30]([CH2:29][CH2:28][C:25]([OH:27])=[O:26])[C:34]3=[O:35])[CH:13]=[CH:12][CH:11]=2)=[CH:18][CH:19]=1)([CH3:2])([CH3:4])[CH3:3]

Participants

5

Reactant 3

HCID 814923-Thiazolidinepropionic acid, 4-oxo-2-thioxo-HCID 517045Sodium AcetateHCID 10824840HCID 10824840, compound

Product 1

HCID 86752508HCID 86752508, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

Under nitrogen atmosphere in a round bottom flask 4-[4-(t-butyl)phenoxy]benzaldehyde (2.0 g, 7.8 mmol) was dissolved in 40 ml of acetic acid with stirring. To this solution was added sodium acetate (2.56 g, 31.2 mmol) followed by the addition of N-(2-carboxyethyl)rhodanine (1.79 g, 8.7 mmol). The reaction mixture was heated to reflux. The progress of the reaction was monitored by thin layer chromatography. The reaction was allowed to reflux overnight.

Workup

  1. temperatureThe reaction mixture was heated to reflux
  2. temperatureto reflux overnight

Sources & evidence

ORD record
ord-80bc24029e4e44f0aac64281d004a2a6
Source dataset
uspto-grants-2001_06
Patent number
US06251928B1

Reaction notes

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