Sodium Acetate → HCID 73568328, compound

HRID 1069127Notes

Reaction equation

HRID 1069127 reaction equation
[C:1]([C:5]1[CH:20]=[CH:19][C:8]([CH2:9][O:10][C:11]2[CH:18]=[CH:17][C:14]([CH:15]=O)=[CH:13][CH:12]=2)=[CH:7][CH:6]=1)([CH3:4])([CH3:3])[CH3:2].[S:21]1[CH2:27][C:25](=[O:26])[NH:24][C:22]1=[S:23].C([O-])(=O)C.[Na+]>C(O)(=O)C>[C:1]([C:5]1[CH:20]=[CH:19][C:8]([CH2:9][O:10][C:11]2[CH:18]=[CH:17][C:14]([CH:15]=[C:27]3[S:21][C:22](=[S:23])[NH:24][C:25]3=[O:26])=[CH:13][CH:12]=2)=[CH:7][CH:6]=1)([CH3:4])([CH3:3])[CH3:2]

Participants

5

Reactant 3

HCID 517045Sodium AcetateHCID 1201546RhodanineHCID 23411144HCID 23411144, compound

Product 1

HCID 73568328HCID 73568328, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

The 4-[(4-t-butyl)benzyloxy]benzaldehyde (2.6 g, 9 mmol) was then coupled with rhodanine (1.4 g, 10.5 mmol) by adding the reactants to sodium acetate (2.9 g, 36 mmol) and acetic acid. The reaction mixture was then heated to reflux and refluxed overnight.

Workup

  1. temperatureThe reaction mixture was then heated
  2. temperatureto reflux
  3. temperaturerefluxed overnight

Sources & evidence

ORD record
ord-fba1f440525441cea59de5c7036d471d
Source dataset
uspto-grants-2001_06
Patent number
US06251928B1

Reaction notes

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