Sodium Acetate → HCID 2854038, compound

HRID 1069128Notes

Reaction equation

HRID 1069128 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][O:9][C:10]2[CH:17]=[CH:16][C:13]([CH:14]=O)=[CH:12][CH:11]=2)=[CH:4][CH:3]=1.C([O-])(=O)C.[Na+].[S:23]1[CH2:29][C:27](=[O:28])[NH:26][C:24]1=[S:25]>C(O)(=O)C>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][O:9][C:10]2[CH:17]=[CH:16][C:13]([CH:14]=[C:29]3[S:23][C:24](=[S:25])[NH:26][C:27]3=[O:28])=[CH:12][CH:11]=2)=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 517045Sodium AcetateHCID 5806474-[(4-Chlorobenzyl)oxy]benzaldehydeHCID 1201546Rhodanine

Product 1

HCID 2854038HCID 2854038, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

Under a nitrogen atmosphere in a round bottom flask 4-[(4-chlorophenyl)methoxy]benzaldehyde (0.40 g, 1.62 mmol) was dissolved in acetic acid (8.1 ml) while stirring. To this solution was added sodium acetate (0.47 g, 5.7 mmol) followed by the addition of rhodanine (0.22 g, 1.65 mmol). The reaction mixture was heated to the reflux temperature and maintained at this temperature. The progress of the reaction was monitored by thin layer chromatography.

Workup

  1. temperatureThe reaction mixture was heated to the reflux temperature
  2. temperaturemaintained at this temperature

Sources & evidence

ORD record
ord-fd0e8fc4935d4f059652da6bdec77b87
Source dataset
uspto-grants-2001_06
Patent number
US06251928B1

Reaction notes

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