Sodium Acetate → HCID 86752512, compound

HRID 1069132Notes

Reaction equation

HRID 1069132 reaction equation
[C:1]([C:9]1[CH:24]=[CH:23][C:12]([CH2:13][O:14][C:15]2[CH:16]=[C:17]([CH:20]=[CH:21][CH:22]=2)[CH:18]=O)=[CH:11][CH:10]=1)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[S:25]1[CH2:31][C:29](=[O:30])[NH:28][C:26]1=[S:27].C([O-])(=O)C.[Na+]>C(O)(=O)C>[C:1]([C:9]1[CH:24]=[CH:23][C:12]([CH2:13][O:14][C:15]2[CH:16]=[C:17]([CH:18]=[C:31]3[S:25][C:26](=[S:27])[NH:28][C:29]3=[O:30])[CH:20]=[CH:21][CH:22]=2)=[CH:11][CH:10]=1)(=[O:8])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

5

Reactant 3

HCID 517045Sodium AcetateHCID 1201546RhodanineHCID 21191286HCID 21191286, compound

Product 1

HCID 86752512HCID 86752512, compoundYield 59%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

The 3-(4-benzoylbenzyloxy)benzaldehyde (2.0 g, 6.3 mmol) was coupled with rhodanine (1.06 g, 8.0 mmol) in the presence of sodium acetate (1.89 g, 22 mmol) and acetic acid (75 ml) essentially as previously described to yield 1.6 grams (59.0%) of the deisred title product.

Sources & evidence

ORD record
ord-70b7049c212d4ee180a4cc1bd058e3eb
Source dataset
uspto-grants-2001_06
Patent number
US06251928B1

Reaction notes

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