Lithium Hydroxide → HCID 178514381, compound

Participants

Reaction Conditions

Reaction Steps

The compound of Example 72 (500 mg) was added to methylene chloride (5 mL) followed by the addition of TFA (2 mL). The reaction was monitored by HPLC. After the reaction was complete the product was freeze dried. The product was added to water/aceonitrile 1:1 (50 mL), followed by the addition of lithium hydroxide (100 mg, 0.4 mmol). The reaction was stirred at 25° C., and monitored by HPLC. After complete hydrolysis the product was extracted with ethyl acetate and dried over Na2SO4 to give a yellow oil (450 mg). NMR and MS were consistent with the proposed structure.

Provenance & Evidence