HCID 9893662, compound → HCID 15550552, compound

HRID 1069182Notes

Reaction equation

HRID 1069182 reaction equation
C(OC1C=CC(N(CC=C(C)C)C2CCN(C(C3CC(C)CCN3CCC(C)C)=O)CC2)=CC=1)C1C=CC=CC=1.C[CH:42]1[CH2:47][CH2:46][N:45]([CH2:48][CH2:49][CH:50]([CH3:52])[CH3:51])[CH:44]([C:53]([OH:55])=[O:54])[CH2:43]1>>[CH3:51][CH:50]([CH3:52])[CH2:49][CH2:48][N:45]1[CH2:46][CH2:47][CH2:42][CH2:43][CH:44]1[C:53]([OH:55])=[O:54]

Participants

3

Reactant 2

HCID 9893662HCID 9893662, compoundHCID 21191064HCID 21191064, compound

Product 1

HCID 15550552HCID 15550552, compoundYield 14%

Procedure

The preparation of Example 17: {4-[(4-Benzyloxy-phenyl)-(3-methyl-but-2-enyl)-amino]-piperidin-1-yl }-[4-methyl-1-(3-methyl-butyl)-piperidin-2-yl]-methanone was made in accordance with the process of Example 11 (Step 3), except that 4-Methyl-1-(3-methyl-butyl)-piperidine-2-carboxylic acid was used instead of 1-(3-Methyl-butyl)-piperidine-2-carboxylic acid (14% yield).

Workup

  1. customThe preparation of Example 17

Sources & evidence

ORD record
ord-ea572db1fae84421aa56b52b1f50f300
Source dataset
uspto-grants-2001_06
Patent number
US06251919B1

Reaction notes

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