Trifluoroacetic acid → HCID 21190971, compound

Participants

Reaction Steps

4-[(4-Cyclohexylmethoxy-phenyl)-(3-methyl-butyl)-amino]-piperidine-1-carboxylic acid tert-butyl ester (40e, 1.08 g, 2.36 mmol) was dissolved in CH2Cl2 (8 mL), treated with TFA (8 mL), and stirred for 30 minutes. The reaction was concentrated in vacuo, diluted with EtOAc (200 mL), washed three times with saturated bicarbonate solution and once with brine, dried over Na2SO4, and concentrated to give 0.78 (92%) of the desired product which was used without further purification.

Provenance & Evidence