3,3-Dimethylbutanal → HCID 21191041, compound

HRID 1069191Notes

Reaction equation

HRID 1069191 reaction equation
[CH3:1][C:2]([CH3:26])=[CH:3][CH2:4][N:5]([C:12]1[CH:17]=[CH:16][C:15]([CH2:18][CH2:19][C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)=[CH:14][CH:13]=1)[CH:6]1[CH2:11][CH2:10][NH:9][CH2:8][CH2:7]1.[CH3:27][C:28]([CH3:33])([CH3:32])[CH2:29][CH:30]=O>>[CH3:27][C:28]([CH3:33])([CH3:32])[CH2:29][CH2:30][N:9]1[CH2:8][CH2:7][CH:6]([N:5]([CH2:4][CH:3]=[C:2]([CH3:26])[CH3:1])[C:12]2[CH:13]=[CH:14][C:15]([CH2:18][CH2:19][C:20]3[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=3)=[CH:16][CH:17]=2)[CH2:11][CH2:10]1

Participants

3

Reactant 2

HCID 763353,3-DimethylbutanalHCID 18380553HCID 18380553, compound

Product 1

HCID 21191041HCID 21191041, compound

Procedure

The preparation of Example 48: [1-(3,3-Dimethyl-butyl)-piperidin4-yl]-(3-methyl-but-2-enyl)-(4-phenethyl-phenyl)-amine was prepared in accordance with the methods of Step 8 in Example 37 except that (3-Methyl-but-2-enyl)-(4-phenethyl-phenyl)-piperidin-4-yl-amine (48g) was used instead of [4-(3,3-Dimethyl-butyl)-phenyl]-(3-methyl-but-2-enyl)-pipendin-4-yl-amine (37g) and 3,3-dimethylbutyraldehyde was used instead of isovaleraldehyde.

Workup

  1. customThe preparation of Example 48

Sources & evidence

ORD record
ord-1558c9c4c8ad4961afd55207e5b1b781
Source dataset
uspto-grants-2001_06
Patent number
US06251919B1

Reaction notes

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