反应详情

温度

100 °C

10.0 g (0.04 mol) of methyl 3-benzyloxyimino-2-oxovalerate and 20 ml of morpholine were combined and the mixture was stirred for 3 hours at 100° C. After distilling the morpholine off under reduced pressure, 100 ml of water was added and the mixture was extracted three times with 100 ml of diethylether. After washing with water and a saturated aqueous sodium chloride followed by anhydrous magnesium sulfate, the solvent was distilled off under reduced pressure to obtain a residue, which was purified by a column chromatography on a silica gel (n-hexane/ethyl acetate) to obtain 6.78 g (yield: 56%) of 4-(3-benzyloxyimino-2-oxovaleryl)morpholine as a white solid.

1. distillationAfter distilling the morpholine off under reduced pressure, 100 ml of water
2. additionwas added
3. extractionthe mixture was extracted three times with 100 ml of diethylether
4. washAfter washing with water
5. distillationthe solvent was distilled off under reduced pressure
6. customto obtain a residue, which
7. customwas purified by a column chromatography on a silica gel (n-hexane/ethyl acetate)