Bromine → HCID 10168999, compound

Participants

Reaction Steps

Prepared from 2,6-dibromo-4-(9-bromo-2,3-dimethyl-naphtho[2,3-b]thiophen-4-yl)-phenol (Example 9) and (S)-2-hydroxy-4-phenyl-butyrate, ethyl ester (Example 27) according to the procedure of Example 30. White solid: [a]25/D=−12.187° (9.929 mg/mL, CHCl3); NMR (DMSO-d6); δ13.24 (s, 1H), 8.21 (d, J=8 Hz, 1H), 7.73 (s, 2H), 7.67 (ddd, J=8, 7, 1 Hz, 1H), 7.52-7.45 (m, 2H), 7.32-7.28 (m, 2H), 7.24-7.20 (m, 3H) 5.02 (d, J=6 Hz, 1H), 2.99-2.86 (m, 1H), 2.75-2.65 (m, 1H), 2.45 (s, 3H), 2.30-2.20 (m, 2H), 1.61 (s, 3H); MS (+FAB): [M+], 3 bromine isotope pattern, 700 (30%), 702 (100%), 704 (90%), 706 (55%); Anal. Calc. for C30H23Br3O3S: C, 51.23; H, 3.30; N, 0.00. Found: C, 51.33; H, 3.33; N, 0.29.

Provenance & Evidence