HuagongsheHuagongshe Chemistry Print Report · For research reference only
Fumaric Acid → 2-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]1-(2,3-dihydro-1H-isoindol-2-yl)ethanone fumarate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Fumaric Acid | HCID 444972 | — |
| Reactant | 2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]-1-(2,3-dihydro-1H-isoindol-2-yl)ethanone | HCID 15285696 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 2-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]1-(2,3-dihydro-1H-isoindol-2-yl)ethanone fumarate | HCID 18467344 | — |
Reaction Steps
Free base (1 g, Example 243B) of 2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]-1-(2,3-dihydro-1H-isoindol-2-yl)ethanone dissolved in hot ethanol (˜10 ml) was treated with a solution of fumaric acid (306 mg) in hot ethanol. The mixture was cooled and the product collected, 1.2 gm, m.p. 223-225° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06251907B1 |
| Source dataset | uspto-grants-2001_06 |
| ORD ID | ord-4e2339dbe87a48ecbc5e75cea9081a9d |
| Source note | uspto-grants-2001_06 |