1-Phenethylamine → 1-Methyl-1,2,3,4-tetrahydroisoquinoline

Participants

Reaction Conditions

Reaction Steps

103.08 g (0.86 mole) of α-methylbenzylamine was dissolved in 110 ml of dichloromethane and 127.56 g (1.02 mole) of 2-bromoethanol was added thereto. This mixture was stirred at 52° C. for 50 hours to complete the reaction. The reaction solution was concentrated under reduced pressure and the residue was subjected to fractional distillation to obtain 109 g of the title compound, which had a pale yellow color.

Provenance & Evidence