2-Bromoethanol → (S)-(-)-N-(2-Hydroxyethyl)-alpha-phenylethylamine

Participants

Reaction Conditions

Reaction Steps

108.23 g (0.903 mmole) of (S)-(−)-α-methylbenzylamine was dissolved in 140 ml of dichloromethane and 144.0 g (1.071 mmole) of 2-bromoethanol was added thereto. This mixture was stirred at 51° C. for 52 hours to complete the reaction. The reaction solution was concentrated under reduced pressure and the residue was subjected to fractional distillation to obtain 117.4 g of the title compound, which had a pale yellow color.

Provenance & Evidence