HRID1069412

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID8471

Triethylamine

C6H15N

HCID92214

1-Methyl-1,2,3,4-tetrahydroisoquinoline

C10H13N

结构：Cc1nc(Nc2ccc(F)cc2)nc(N2CCc3ccccc3C2C)c1C

HCID204104

N-(4-Fluorophenyl)-4,5-dimethyl-6-(1-methyl-3,4-dihydro-2(1H)-isoquinolinyl)-2-pyrimidinamine

C22H23FN4

HCID9992376

4-Chloro-N-(4-fluorophenyl)-5,6-dimethylpyrimidin-2-amine

C12H11ClFN3

PRODUCTS

生成物

结构：Cc1nc(Nc2ccc(F)cc2)nc(N2CCc3ccccc3C2C)c1C.Cl

HCID204103

N-(4-Fluorophenyl)-4,5-dimethyl-6-(1-methyl-3,4-dihydroisoquinolin-2(1H)-yl)pyrimidin-2-amine--hydrogen chloride (1/1)

C22H24ClFN4

收率 91%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID174

Ethylene glycol

C2H6O2

溶剂HCID263

1-Butanol

C4H10O

PROCEDURE

实验过程

8.12 g (11.2 ml, 80.3 mmole) of triethylamine, 30 ml of n-butanol and 6.58 g (44.1 mmole) of 1-methyl-1,2,3,4-tetrahydroisoquinoline were added to 40 ml of ethylene glycol. 10.1 g (40.1 mmole) of 4-chloro-2-(4-fluorophenylamino)-5,6-dimethylpyrimidine was added thereto and then reacted at 130° C. for 30 hours under refluxing to prepare 5,6-dimethyl-2-(4-fluorophenylamino)-4-(1-methyl-1,2,3,4-tetrahydroisoquinolin-2-yl)-pyrimidine. This product was treated according to the procedure detailed in Example 14 to obtain 14.7 g of purified 5,6-dimethyl-2-(4-fluorophenylamino)-4-(1-methyl-1,2,3,4-tetrahydroisoquinolin-2-yl)pyrimidine hydrochloride.

WORKUP

后处理

customreacted at 130° C. for 30 hours
temperatureunder refluxing
additionThis product was treated