Propylene Glycol → Revaprazan Hydrochloride

Participants

Reaction Steps

720 ml of triethylamine and 695 g (4.72 mmole) of 1-methyl-1,2,3,4-tetrahydroisoquinoline were added to 2100 ml of 1,2-propylene glycol. 1179 g (4.68 mmole) of 4-chloro-2-(4-fluorophenylamino)-5,6-dimethylpyrimidine was added thereto and the mixture thereby obtained was reacted at 130° C. for 58 hours to prepare 5,6-dimethyl-2-(4-fluorophenylamino)-4-(1-methyl- 1,2,3,4-tetrahydroisoquinolin-2-yl)pyrimidine. This product was treated according to the procedure detailed in Example 14 to obtain 1250 g of purified 5,6-dimethyl-2-(4-fluorophenylamino)-4-(1-methyl-1,2,3,4-tetrahydroisoquinolin-2-yl)pyrimidine hydrochloride.

Provenance & Evidence