HuagongsheHuagongshe Chemistry Print Report · For research reference only
5,6-Dimethoxy-1-indanone → Donepezil
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5,6-Dimethoxy-1-indanone | HCID 75018 | — |
| Reactant | 1-Benzylpiperidine-4-carbaldehyde | HCID 89584 | — |
| Reactant | Lithium diisopropylamide | HCID 2724682 | — |
| Product | Donepezil | HCID 3152 | — |
Reaction Steps
As it was disclosed in Example 3 and 4 of JP-A 64-79151(1989), indanone derivative was produced by reacting 5,6-dimethoxy-1-indanone with 1-benzyl-4-formylpiperidine in the presence of strong base such as lithium diisopropylamide (Example 3), followed by reduction (Example 4) for example. According to this method, yield for Donepezil through Example 3 and 4 was 50.8% (62%×82%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06252081B1 |
| Source dataset | uspto-grants-2001_06 |
| ORD ID | ord-b08503b745ae44b6b3adc8bc1144e125 |
| Source note | uspto-grants-2001_06 |