Ethanol → HCID 21191786, compound

HRID 1069446Notes

Reaction equation

HRID 1069446 reaction equation
[OH-].[Na+].C(O)C.[NH2:6][C:7]1[C:8](=[O:28])[N:9]([CH2:23][C:24]([O:26]C)=[O:25])[C:10]([CH3:22])=[CH:11][C:12]=1[S:13]([C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)(=[O:15])=[O:14]>ClCCl>[NH2:6][C:7]1[C:8](=[O:28])[N:9]([CH2:23][C:24]([OH:26])=[O:25])[C:10]([CH3:22])=[CH:11][C:12]=1[S:13]([C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)(=[O:14])=[O:15]

Participants

5

Reactant 3

HCID 702EthanolHCID 14798Sodium HydroxideHCID 70185215HCID 70185215, compound

Product 1

HCID 21191786HCID 21191786, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

5.7 ml of a 1 N aqueous sodium hydroxide solution and 5.7 ml of ethanol are added to 1.6 g (4.76 mmol) of methyl 3-amino-6-methyl-2-oxo-4-(phenylsulphonyl)-1,2-dihydropyridine-1-acetate. 1.5 ml of dichloromethane are then introduced and the mixture is kept stirred for 2 hours at room temperature. The reaction medium is concentrated under vacuum and 8 ml of water and 5.8 ml of a 1 N aqueous hydrochloric acid solution are added. The precipitate is filtered, it is rinsed with water and it is dried under vacuum.

Workup

  1. concentrationThe reaction medium is concentrated under vacuum and 8 ml of water and 5.8 ml of a 1 N aqueous hydrochloric acid solution
  2. additionare added
  3. filtrationThe precipitate is filtered
  4. washit is rinsed with water and it
  5. customis dried under vacuum

Sources & evidence

ORD record
ord-e4bfc46f3a7a47d895c63a3471b8e6a9
Source dataset
uspto-grants-2001_06
Patent number
US06252082B1

Reaction notes

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