HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phosphorus trichloride → MW88KT29DZ
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phosphorus trichloride | HCID 24387 | — |
| Reactant | 4-Chlorobenzylamine | HCID 66036 | — |
| Reactant | 8-Hydroxyquinoline-7-carboxylic Acid | HCID 231363 | — |
| Solvent | Water | HCID 962 | — |
| Product | MW88KT29DZ | HCID 10470802 | 21.3% |
Reaction Steps
A solution of 8-hydroxyquinoline-7-carboxylic acid (0.250 g) of Preparation 1 and 4-chlorobenzylamine (0.187 g) in 25 mL xylenes is heated to reflux. To this is added dropwise PCl3 (0.073 g). Refluxing is continued overnight. The reaction is then cooled and water is added to destroy excess PCl3. The resulting solid is collected and recrystallized from EtOAc/hexanes to yield 0.088 g of the title product as a yellow solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06252080B1 |
| Source dataset | uspto-grants-2001_06 |
| ORD ID | ord-65d46ef21629466aabfafe5ae82dff44 |
| Source note | uspto-grants-2001_06 |