HuagongsheHuagongshe Chemistry Print Report · For research reference only
Clioquinol → HCID 18372618, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Clioquinol | HCID 2788 | — |
| Reactant | tert-Butyldimethylsilyl chloride | HCID 28928 | — |
| Product | HCID 18372618 | HCID 18372618 | — |
Reaction Steps
The title compound is prepared in two steps from 5-chloro-8-hydroxy-7-iodoquinoline, which is commercially available, according to the procedures described in Preparation 11 and Example 41, substituting trimethylchlorosilane for t-butyldimethylchlorosilane in the former procedure. Column chromatography (elution with 0-1% EtOAc/hexane) gives 0.147 g of the title compound as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06252080B1 |
| Source dataset | uspto-grants-2001_06 |
| ORD ID | ord-75c3e49ca258470da54e3f0a4525300f |
| Source note | uspto-grants-2001_06 |