HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 70240736, compound → HCID 21191856, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 70240736 | HCID 70240736 | — |
| Catalyst | Nickel | HCID 935 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 21191856 | HCID 21191856 | — |
Reaction Steps
Using the method described in Example 3, Part D, 40 mg (0.11 mmol) of 5-hydrazinocarbonyl-2-methyl-1-(phenylmethyl)-1H-indole-3-acetic acid hydrazide was hydrogenolized using approximately 1 g of Raney nickel in 50 mL of EtOH to give after chromatography on silica (gradient, CH2Cl2→8% MeOH/CH2Cl2) 17 mg (50% yield) of 5-aminocarbonyl-2-methyl-1-(phenylmethyl)-1H-indole-3-acetamide.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06252084B1 |
| Source dataset | uspto-grants-2001_06 |
| ORD ID | ord-b3993875142641e28ca29ab13b6af27d |
| Source note | uspto-grants-2001_06 |