4-Acetylbenzoic Acid → HCID 10237329, compound

HRID 10696Notes

Reaction equation

HRID 10696 reaction equation
[CH3:1][O:2][C:3]1[CH:10]=[C:9]([O:11][CH3:12])[C:8]([C:13]2[CH:14]=[N:15][NH:16][CH:17]=2)=[CH:7][C:4]=1[CH:5]=O.[C:18]([C:21]1[CH:29]=[CH:28][C:24]([C:25]([OH:27])=[O:26])=[CH:23][CH:22]=1)(=[O:20])[CH3:19]>>[CH3:1][O:2][C:3]1[CH:10]=[C:9]([O:11][CH3:12])[C:8]([C:13]2[CH:14]=[N:15][NH:16][CH:17]=2)=[CH:7][C:4]=1/[CH:5]=[CH:19]/[C:18]([C:21]1[CH:29]=[CH:28][C:24]([C:25]([OH:27])=[O:26])=[CH:23][CH:22]=1)=[O:20]

Participants

3

Reactant 2

HCID 114704-Acetylbenzoic AcidHCID 219810912,4-dimethoxy-5-(1H-pyrazol-4-yl)-benzaldehyde

Product 1

HCID 10237329HCID 10237329, compound

Procedure

The title compound was prepared by condensing 2,4-dimethoxy-5-(1H-pyrazol-4-yl)-benzaldehyde (Ex-74B) and 4-acetylbenzoic acid in a similar manner as described in Ex-3 including an acid work-up. Yellow solid, mp>250° C. 1H-NMR (DMSO-d6) δ 12.42 (bs, 1H), 8.20–8.03 (m, 8H), 7.85 (d, J=16.1 Hz), 6.74 (s, 1H), 3.95 (s, 3H), 3.94 (s, 3H). MS m/z=379 ([M+H]+, 100%).

Sources & evidence

ORD record
ord-b1fce6fa86b44b33a213046a373ec11e
Source dataset
uspto-grants-2006_08
Patent number
US07094801B2

Reaction notes

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