反应详情

A mixture of 211 mg (0.05 mmol) of [4-[[3-(2-amino-2-oxoethyl)-2-ethyl-1-(phenylmethyl)-1-H-indol-5-yl]oxy]butanoic acid ethyl ester and 1 mL of hydrazine in 5 mL of ethanol was heated to maintain reflux for 5 hours. The mixture was diluted with water, extracted with ethyl acetate, the ethyl acetate washed with brine, dried (MgSO4), and concentrated at reduced pressure. The residue was stirred with MeOH and the insoluble material filtered to give 177 mg (37% yield) of 2-ethyl-5-(4-hydrazino-4-oxobutoxy)-1-(phenylmethyl)-1H-indole-3-acetamide, mp, 176-179° C.

1. temperaturewas heated
2. temperatureto maintain
3. temperaturereflux for 5 hours
4. extractionextracted with ethyl acetate
5. washthe ethyl acetate washed with brine
6. dry with materialdried (MgSO4)
7. concentrationconcentrated at reduced pressure
8. filtrationthe insoluble material filtered