HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → (z)-5-[2,3-Dihydro-3-[(3-methoxy-1h-pyrrol-2-yl)methylene]-2-oxo-1h-indol-4-yl]-4-pentynoic acid sodium salt
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | (Z)-5-[2,3-Dihydro-3-[(3-methoxy-1H-pyrrol-2-yl)methylene]-2-oxo-1H-indol-4-yl]-4-pentynoic acid | HCID 9797846 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | (z)-5-[2,3-Dihydro-3-[(3-methoxy-1h-pyrrol-2-yl)methylene]-2-oxo-1h-indol-4-yl]-4-pentynoic acid sodium salt | HCID 23683387 | — |
Reaction Steps
(Z)-5-[2,3-Dihydro-3-[(3-methoxy-1H-pyrrol-2-yl)methylene]-2-oxo-1H-indol-4-yl]-4-pentynoic acid (100 mg, 3 mmol) (from Example 10 above) was dissolved in tetrahydrofuran (1 mL), and 1N sodium hydroxide (3 mL) was added. The resulting product, (Z)-5-[2,3-dihydro-3-[(3-methoxy-1H-pyrrol-2-yl)methylene]-2-oxo-1H-indol-4-yl]-4-pentynoic acid sodium salt, was purified via reverse-phase HPLC (acetonitrile—water over 15 minutes).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06252086B1 |
| Source dataset | uspto-grants-2001_06 |
| ORD ID | ord-6e51d0a6e70441fd9eae328f627e5354 |
| Source note | uspto-grants-2001_06 |