HuagongsheHuagongshe Chemistry Print Report · For research reference only
Imidazole → (S)-N-Boc-2-amino-1(-tert-butyldimethylsilyloxy)-but-3-yne
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Imidazole | HCID 795 | — |
| Reactant | tert-Butyldimethylsilyl chloride | HCID 28928 | — |
| Reactant | (S)-Tert-butyl (1-hydroxybut-3-YN-2-YL)carbamate | HCID 21971753 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | (S)-N-Boc-2-amino-1(-tert-butyldimethylsilyloxy)-but-3-yne | HCID 21971752 | — |
Reaction Steps
(S)-N-Boc-2-amino-1 (-tert-butyldimethylsilyloxy)-but-3-yne was prepared by the treatment of (S)-N-Boc-2-amino-but-3-yn-1-ol (120 mg, 0.65 mmol) (Example 115A above) with imidazole (110 mg, 1.29 mmol) (Aldrich) and tert-butyldimethylsilyl chloride (120 mg, 0.77 mmol) (Fluka) in CH2Cl2 (10 mL) according to the procedure described above in Example 104B. (Yield 190 mg, 98%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06252086B1 |
| Source dataset | uspto-grants-2001_06 |
| ORD ID | ord-37572a4ca48145bdb77347483d20f65d |
| Source note | uspto-grants-2001_06 |