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HRID 1069774作成日：2026年10月25日
Ethyl 5-formyl-4-methyl-1h-pyrrole-3-carboxylate → (Z)-5-(5-Fluoro-4-iodo-2-oxo-1,2-dihydro-indol-3-ylidenemethyl)-4-methyl-1H-pyrrole-3-carboxylic acid ethyl ester
https://huagongshe.com/reaction/1069774
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Ethyl 5-formyl-4-methyl-1h-pyrrole-3-carboxylate | HCID 236067 | — |
| 反応物 | 5-Fluoro-4-iodoindolin-2-one | HCID 9795601 | — |
| 溶媒 | Isopropanol | HCID 3776 | — |
| 溶媒 | Piperidine | HCID 8082 | — |
| 生成物 | (Z)-5-(5-Fluoro-4-iodo-2-oxo-1,2-dihydro-indol-3-ylidenemethyl)-4-methyl-1H-pyrrole-3-carboxylic acid ethyl ester | HCID 20667774 | — |
反応手順
A suspension of 1,3-dihydro-5-fluoro-4-iodo-2H-indol-2-one (0.5 g, 1.8 mmol) (Example 2A) and 5-formyl-4-methyl-1H-pyrrole-3-carboxylic acid ethyl ester (0.39 g, 2.17 mmol) (Example 116A above) in 1% piperidine in 2-propanol (6 mL) was heated at 80° C. for 3 h. The precipitate was collected and washed with water to give (Z)-5-(5-Fluoro-4-iodo-2-oxo-1,2-dihydro-indol-3-ylidenemethyl)-4-methyl-1H-pyrrole-3-carboxylic acid ethyl ester. (Yield 0.67 g, 85%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 特許番号 | US06252086B1 |
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| 出典データセット | uspto-grants-2001_06 |
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| ORD ID | ord-aa5e6c964156427bacc573f7b7a627b0 |
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| 出典メモ | uspto-grants-2001_06 |
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