HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → 8-Ethyl-6-ethynyl-2,2,4,4-tetramethylchroman
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 8-Ethyl-6-trimethylsilanylethynyl-2,2,4,4-tetramethyl chroman | HCID 69548613 | — |
| Solvent | Hexane | HCID 8058 | — |
| Product | 8-Ethyl-6-ethynyl-2,2,4,4-tetramethylchroman | HCID 22569019 | — |
Reaction Steps
Following general procedure E and using 8-ethyl-6-trimethylsilanylethynyl-2,2,4,4-tetramethyl chroman (Intermediate 47, 0.137 g, 0.44 mmol), methanol and potassium carbonate (0.1 g, 0.72 mmol) followed by flash column chromatography over silica gel (230-400 mesh) using 5% ethyl acetate in hexane as the eluent, the title compound was obtained as an oil (0.066 g, 62%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06252090B1 |
| Source dataset | uspto-grants-2001_06 |
| ORD ID | ord-331e1c845f034976b1c1ab434c862219 |
| Source note | uspto-grants-2001_06 |