Sodium Hydroxide → HCID 22344592, compound

HRID 1070202Notes

Reaction equation

[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:22]=[CH:23][C:24]=1[O:25][CH2:26][C:27]1[N:28]=[C:29]([C:33]2[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=2)[O:30][C:31]=1[CH3:32])[CH2:6][O:7]/[N:8]=[C:9](/[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)\[CH2:10][CH2:11][C:12]([O:14]C)=[O:13].[OH-].[Na+]>>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:22]=[CH:23][C:24]=1[O:25][CH2:26][C:27]1[N:28]=[C:29]([C:33]2[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=2)[O:30][C:31]=1[CH3:32])[CH2:6][O:7]/[N:8]=[C:9](/[C:16]1[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=1)\[CH2:10][CH2:11][C:12]([OH:14])=[O:13]

Participants

Reactant 2

HCID 14798Sodium Hydroxide

HCID 22344580HCID 22344580, compound

Product 1

HCID 22344592HCID 22344592, compoundYield 81.2%

Procedure

In substantially the same manner as in example 148. methyl E-4-[3-methoxy-4(5-methyl-2-phenyl-4-oxazolylmethoxy)benzyloxyimino]-4-phenylbutyrate (1.00 g) was reacted with 1N aqueous sodium hydroxide to obtain E-4-[3-methoxy-4-(5-methyl-2-phenyl-4-oxazolylmethoxy)benzyloxyimino]-4-phenylbutyric acid (790 mg, yield 80%). Recrystallization from ethanol-isopropyl ether gave colorless prisms. m.p. 134-135° C.

Sources & evidence

ORD record: ord-9c38050901a54d42b5fadb329543d0b3
Source dataset: uspto-grants-2001_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06251926B1

Reaction notes

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