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HRID 1070226作成日：2026年10月27日

N,N-diethyl-m-toluamide → N,N-Diethyl-5-methyl-2-(trimethylsilyl)benzamide

https://huagongshe.com/reaction/1070226

反応式

関与物質

役割名称HCID仕込み量
反応物N,N-diethyl-m-toluamideHCID 4284—
反応物ChlorotrimethylsilaneHCID 6397—
生成物N,N-Diethyl-5-methyl-2-(trimethylsilyl)benzamideHCID 1863027546%

反応手順

These compounds were prepared from N,N-diethyl-3-methylbenzamide and 2.0 eq TMSCl according to General Method A. Purification by HPLC using 1:9 ethyl acetate/hexanes gave two products. Compound 63 was isolated as 6.0 g of a clear oil, a 46% yield. Compound 64 was isolated as 2.3 g of a clear oil, a 17% yield.

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US06252078B1
出典データセットuspto-grants-2001_06
ORD IDord-d4b8fa9a25e146a6a8cf4057d2e18947
出典メモuspto-grants-2001_06