HCID 10704912, compound → HCID 86757084, compound

HRID 1070324Notes

Reaction equation

HRID 1070324 reaction equation
[C:1]([OH:6])(=[O:5])[C:2]([OH:4])=[O:3].[C:7]([OH:12])(=[O:11])[C:8]([OH:10])=[O:9].O[C:14]1[C:15]([O:56][CH3:57])=[CH:16][C:17]2[C:21](CC3C=CC(O[C@@H]4CCCC[C@H]4N4CCCC4)=CC=3)=[C:20]([C:41]3[CH:46]=[CH:45][C:44]([O:47][CH2:48][CH2:49][N:50]4[CH2:54][CH2:53][CH2:52][CH2:51]4)=[CH:43][CH:42]=3)[S:19][C:18]=2[CH:55]=1.[CH3:58][O:59][C:60]1[CH:61]=[C:62]([CH:66]=[CH:67][C:68]=1[CH2:69][N:70]1[CH2:74][CH2:73][CH2:72][CH2:71]1)[C:63](O)=O>>[C:1]([OH:6])(=[O:5])[C:2]([OH:4])=[O:3].[C:7]([OH:12])(=[O:11])[C:8]([OH:10])=[O:9].[CH3:57][O:56][C:15]1[CH:14]=[CH:55][C:18]2[S:19][C:20]([C:41]3[CH:42]=[CH:43][C:44]([O:47][CH2:48][CH2:49][N:50]4[CH2:54][CH2:53][CH2:52][CH2:51]4)=[CH:45][CH:46]=3)=[C:21]([CH2:63][C:62]3[CH:66]=[CH:67][C:68]([CH2:69][N:70]4[CH2:74][CH2:73][CH2:72][CH2:71]4)=[C:60]([O:59][CH3:58])[CH:61]=3)[C:17]=2[CH:16]=1

Participants

3

Reactant 2

HCID 10704912HCID 10704912, compoundHCID 86757085HCID 86757085, compound

Product 1

HCID 86757084HCID 86757084, compoundYield 37%

Procedure

The free base of the title compound was prepared in 37% yield by essentially following the procedures outlined in Example 41; Part C from 5-methoxy-2-[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]benzo[b]thiophene (Example 71, Part C) and 3-methoxy-4-[(1-pyrrolidinyl)methyl]benzoic acid (Example 41, Part B). The title compound was prepared by essentially following the procedures outlined in Example 21, Part C from the free base.

Workup

  1. customThe title compound was prepared

Sources & evidence

ORD record
ord-e98fe0c66c9048dcb72687f39632802c
Source dataset
uspto-grants-2001_06
Patent number
US06251921B1

Reaction notes

Loading…