HRID1070326

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID22994338

未命名化合物

结构：Cc1cc(Cc2c(-c3ccc(OCCC4CCCN4)nc3)sc3cc(O)ccc23)ccc1CN1CCCC1.O=C(O)C(=O)O.O=C(O)C(=O)O

HCID86757087

未命名化合物

PRODUCTS

生成物

结构：COc1cc(-c2sc3cc(O)ccc3c2Cc2ccc(CN3CCCC3)c(C)c2)ccc1OCCN1CCCC1.O=C(O)C(=O)O.O=C(O)C(=O)O

HCID86757088

未命名化合物

收率 30%

PROCEDURE

实验过程

The title compound was prepared from 6-benzyloxy-2-(dimethylamino)benzo[b]thiophen-3-yl 3-methyl-4-[(1-pyrrolidinyl)methyl]phenyl ketone (Example 124, Part C) and 4-bromo-2-methoxyphenyl 2-(1-pyrrolidinyl)ethyl ether (Part A) in 30% yield after PrepLC (SiO2; gradient of 80:15:5 to 70:25:5 hexanes-THF-TEA) by essentially following the procedure detailed in Example 123, Part A.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-736fbb5143ce47a98ca6b299ee74627a
来源数据集: uspto-grants-2001_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06251921B1
来源说明: uspto-grants-2001_06

反应 SMILES

[C:1]([OH:6])(=[O:5])[C:2]([OH:4])=[O:3].[C:7]([OH:12])(=[O:11])[C:8]([OH:10])=[O:9].[OH:13][C:14]1[CH:15]=[CH:16][C:17]2[C:21]([CH2:22][C:23]3[CH:28]=[CH:27][C:26]([CH2:29][N:30]4[CH2:34][CH2:33][CH2:32][CH2:31]4)=[C:25]([CH3:35])[CH:24]=3)=[C:20](C3C=CC(OCCC4CCCN4)=NC=3)[S:19][C:18]=2[CH:50]=1.[N:51]1([CH2:56][CH2:57][O:58][C:59]2[CH:64]=[CH:63][C:62](Br)=[CH:61][C:60]=2[O:66][CH3:67])[CH2:55][CH2:54][CH2:53][CH2:52]1>>[C:1]([OH:6])(=[O:5])[C:2]([OH:4])=[O:3].[C:7]([OH:12])(=[O:11])[C:8]([OH:10])=[O:9].[OH:13][C:14]1[CH:15]=[CH:16][C:17]2[C:21]([CH2:22][C:23]3[CH:28]=[CH:27][C:26]([CH2:29][N:30]4[CH2:34][CH2:33][CH2:32][CH2:31]4)=[C:25]([CH3:35])[CH:24]=3)=[C:20]([C:62]3[CH:63]=[CH:64][C:59]([O:58][CH2:57][CH2:56][N:51]4[CH2:55][CH2:54][CH2:53][CH2:52]4)=[C:60]([O:66][CH3:67])[CH:61]=3)[S:19][C:18]=2[CH:50]=1