HuagongsheHuagongshe Chemistry Print Report · For research reference only
Lithium hydroxide, monohydrate → HCID 70186151, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Lithium hydroxide, monohydrate | HCID 168937 | — |
| Reactant | HCID 70186562 | HCID 70186562 | — |
| Solvent | Methanol tetrahydrofuran water | HCID 21892291 | — |
| Product | Ethyl acetate methanol ammonium hydroxide | HCID 21901312 | — |
| Product | HCID 70186151 | HCID 70186151 | 220.1% |
Reaction Steps
O-[4-[3-[4-[2-(1-Pyrrolidinyl)ethoxy]benzyl]benzo[b]thiophen-2-yl]phenyl]-L-serine methyl ester (21 mg) was dissolved in THF:MeOH:H2O (3:1:1, 3 mL), treated with LiOH-H2O (5 mg) in one portion and allowed to stir at ambient temperature for 3 h. The reaction mixture was concentrated under reduced pressure. Chromatography with NH4OH:MeOH:EtOAc (10:20:70) afforded the title compound (15 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06251921B1 |
| Source dataset | uspto-grants-2001_06 |
| ORD ID | ord-07faa2c51e614a06acb7ae9e2f344b33 |
| Source note | uspto-grants-2001_06 |