Sodium borohydride → HCID 22396302, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 5-pyridin-2yl-benzofuran-2-carboxylic acid (770 mg, 2.9 mmol) in 28 mL t-butanol and 2.5 mL methanol was added NaBH4 (275 mg, 7.2 mmol). The mixture was heated at 50° C. under argon overnight, allowed to cool, poured into brine, extracted with ethyl acetate, washed with brine, dried (MgSO4), and evaporated. Purification by chromatography gave 404 mg of (5-pyridin-2-yl-benzofuran-2-yl)-methanol. MS: (M+H)+=226.

Provenance & Evidence