Water → (5-Pyridazin-4-yl-benzofuran-2-yl)-methanol

HRID 1070390ノート

反応式

HRID 1070390 の反応式
Br[C:2]1[CH:3]=[CH:4][C:5]2[O:9][C:8]([CH2:10][OH:11])=[CH:7][C:6]=2[CH:12]=1.C([SnH2][C:18]1[CH:23]=[CH:22][N:21]=[N:20][CH:19]=1)(C)(C)C.O>C1(C)C=CC=CC=1.C1C=CC([P]([Pd]([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1>[N:20]1[CH:19]=[CH:18][C:23]([C:2]2[CH:3]=[CH:4][C:5]3[O:9][C:8]([CH2:10][OH:11])=[CH:7][C:6]=3[CH:12]=2)=[CH:22][N:21]=1

参加物

6

反応物 3

HCID 962WaterHCID 2795537(5-Bromo-1-benzofuran-2-yl)methanolHCID 873176534-Tert-butylstannanyl-pyridazine

生成物 1

HCID 22396275(5-Pyridazin-4-yl-benzofuran-2-yl)-methanol

試薬・触媒・溶媒 2

HCID 178418397HCID 178418397、化合物触媒HCID 1140Toluene溶媒

反応条件

温度
95 °C

実験手順

To a solution of (5-bromo-benzofuran-2-yl)-methanol (1.6 g, 3.7 mmol) and 4-tert-butylstannanyl-pyridazine (1 g; 4.4 mmol) in 15 mL dry toluene, was added tetrakis(triphenylphosphine)palladium (0) (130 mg). The mixture was stirred at 95° C. overnight. After allowing the mixture to come to room temperature, the solution was poured into water, extracted, dried over MgSO4, and filtrated to afford 2.4 g of crude product that was further purified by chromatography to afford (5-pyridazin-4-yl-benzofuran-2-yl)-methanol.

後処理

  1. customto come to room temperature
  2. extractionextracted
  3. dry with materialdried over MgSO4
  4. filtrationfiltrated
  5. customto afford 2.4 g of crude product that
  6. customwas further purified by chromatography

出典と根拠

ORDレコード
ord-0f36db1a01f046d0ae021a045dd28b28
出典データセット
uspto-grants-2005_06
特許番号
US06903086B2

反応ノート

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