関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Pyridine | HCID 1049 | — |
| 反応物 | Phosgene | HCID 6371 | — |
| 反応物 | (1,1'-Biphenyl)-4-methanol | HCID 19186 | — |
| 反応物 | Methyl 2-amino-5-phenylbenzoate | HCID 16768797 | — |
| 触媒 | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | 4-(Biphenyl-4-ylmethoxycarbonylamino)-biphenyl-3-carboxylic acid methyl ester | HCID 69686982 | — |
反応手順
To a solution of methyl-5-phenyl-2-aminobenzoate (0.40 g, 1.76 mmol) and pyridine (0.285 mL, 3.52 mmol) in toluene (7 mL) at room temperature under argon was added 20% phosgene in toluene (1.32 mL, 2.55 mmol) and the mixture was heated at 90° C. for 1 h. The mixture was filtered, and the filtrate was concentrated to dryness. The crude material was dissolved in toluene (10 mL), biphenyl-4-methanol (0.270 g, 1.46 mmol) and DMAP (0.018 g, 0.146 mmol) were added and the mixture was heated at 90° C. for 18 h. The solvent was evaporated to dryness to give 0.51 g of 4-(biphenyl-4-ylmethoxycarbonylamino)-biphenyl-3-carboxylic acid methyl ester.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US06903086B2 |
|---|
| 出典データセット | uspto-grants-2005_06 |
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| ORD ID | ord-fe88d1ad620a40e2a04a16d10d0d96d6 |
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| 出典メモ | uspto-grants-2005_06 |
|---|
