HCID 69688057, compound → HCID 22396304, compound

Participants

Reaction Conditions

Reaction Steps

(3-Oxo-1,3-dihydrobenzo[c]isoxazol-4-yl)carbamic acid 5-(4-fluorophenyl)benzofuran-2-ylmethyl ester (70 mg, 0.17 mmol) was dissolved in 2M H2SO4 at room temperature. Zinc dust was added and the mixture was stirred at 80° C. for 4 hours. Upon cooling, the mixture was filtered. The filtrate was neutralized with diluted NaOH and extracted with CH2Cl2. The organic extracts were dried over anhydrous Na2SO4 and concentrated en vacuo to give 23 mg (32.86%) of 2-amino-6-[5-(4-fluorophenyl)benzofuran-2-ylmethoxycarbonylamino]benzoic acid 701, as a tan powder: mp: 176.4-178.5° C. Anal Calcd for C23H17FN2O5: C, 65.71; H, 4.08; N, 6.66. Found: C, 66.71; H, 4.56; N, 5.95.

Provenance & Evidence