Diethyl Ether → 10-[4-((3r)-3-Hydroxy-2-methyl-cyclohex-1-en-1-yl)-3-methyl-benzoyl]-10,11-dihydro-5h-pyrrolo[2,1-c][1,4]benzodiazepine-3-carboxylic acid methyl-pyridin-3-yl methyl-amide l-(+)-tartaric acid salt

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Reaction Steps

10-[4-((3R)-3-Hydroxy-2-methyl-cyclohex-1-en-1-yl)-3-methyl-benzoyl]-10,11-dihydro-5H-pyrrolo[2,1-c][1,4]benzodiazepine-3-carboxylic acid methyl-pyridin-3-yl methyl-amide (0.120 g, 0.214 mmol) of Example 3, was dissolved in boiling diethyl ether. A solution of L-(+)-tartaric acid (0.0320 g, 0.214 mmol) in hot methanol (1 mL) was added, the mixture cooled and solvent evaporated. Diethyl ether was added to the residue causing a white solid to form which was filtered and dried in vacuo to afford 0.152 g of the title compound as the tartaric acid salt.

Provenance & Evidence