(4-Chlorophenoxy)acetic acid → HCID 22396171, compound

HRID 1070493Notes

Reaction equation

HRID 1070493 reaction equation
[Cl:1][C:2]1[CH:12]=[CH:11][C:5]([O:6][CH2:7][C:8]([OH:10])=O)=[CH:4][CH:3]=1.[NH2:13][CH:14]1[CH2:19][CH2:18][N:17]([C:20]([O:22][C:23]([CH3:26])([CH3:25])[CH3:24])=[O:21])[CH2:16][CH2:15]1>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:6][CH2:7][C:8]([NH:13][CH:14]2[CH2:15][CH2:16][N:17]([C:20]([O:22][C:23]([CH3:26])([CH3:25])[CH3:24])=[O:21])[CH2:18][CH2:19]2)=[O:10])=[CH:11][CH:12]=1

Participants

3

Reactant 2

HCID 26229(4-Chlorophenoxy)acetic acidHCID 12682914-Amino-1-Boc-piperidine

Product 1

HCID 22396171HCID 22396171, compoundYield 63.7%

Procedure

Prepared following the method of Example 94 using (4-chlorophenoxy)acetic acid (0.50 g), 1,1-carbonyldiimidazole (0.50 g) and tert-butyl 4-amino-1-piperidinecarboxylate (0.46 g) to give the subtitle compound (0.54 g).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-ab347f27639b433cb8b6061a7d0ac2e6
Source dataset
uspto-grants-2005_06
Patent number
US06903085B1

Reaction notes

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