HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 2-Chloro-N-[1-[(3,4-difluorophenyl)methyl]-piperidin-4-yl]-acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Chloroacetyl chloride | HCID 6577 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 1-(3,4-Difluorobenzyl)piperidin-4-amine dihydrochloride | HCID 53256127 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Solvent | Sodium chloride; water | HCID 57417360 | — |
| Product | 2-Chloro-N-[1-[(3,4-difluorophenyl)methyl]-piperidin-4-yl]-acetamide | HCID 22396182 | 22.6% |
Reaction Steps
1-[(3,4-Difluorophenyl)methyl]-piperidin-4-ylamine dihydrochloride (3.18 g) was dissolved in tetrahydrofuran (40 ml). Diisopropylethlamine (6.84 g) and chloroacetyl chloride (1.33 g) were added. After 3 hours water, brine and ethyl acetate were added the phase were separated. The organic phase was dried, filtered and evaporated and the residue was purified by chromatography eluting with ethyl acetate to give the subtitle compound (0.728 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06903085B1 |
| Source dataset | uspto-grants-2005_06 |
| ORD ID | ord-cc62249076d64857a51d9fc8ac260f00 |
| Source note | uspto-grants-2005_06 |