HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-Hydroxypicolinimidamide → cis-2-[3-(2-Pyridinyl)-1,2,4-oxadiazol-5-yl]cyclopropanecarboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-Hydroxypicolinimidamide | HCID 120564 | — |
| Reactant | 3-Oxabicyclo(3.1.0)hexane-2,4-dione | HCID 2734721 | — |
| Catalyst | Dimethylformamide | HCID 6228 | — |
| Product | cis-2-[3-(2-Pyridinyl)-1,2,4-oxadiazol-5-yl]cyclopropanecarboxylic acid | HCID 12018241 | 86.6% |
Reaction Steps
N′-hydroxy-2-pyridinecarboximidamide (0.137 g) with 3-oxabicyclo[3.1.0]hexane-2,4-dione (0.112 g) in dimethylformamide (2 drops) was heated for 4 times 30 seconds in a CEM MARS 5 microwave at 100% of 300 W to leave a fused mass. The reaction was allowed to cool and triturated with diethyl ether and filtered to leave cis-2-[3-(2-pyridinyl)-1,2,4-oxadiazol-5-yl]cyclopropanecarboxylic acid (0.200 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06903085B1 |
| Source dataset | uspto-grants-2005_06 |
| ORD ID | ord-eef35b8aea374f8f847d816dbaa9eb88 |
| Source note | uspto-grants-2005_06 |