反应详情

To a solution of methyl-2-bromomethyl-3-nitro-benzoate (6.9 gm, 0.025 mol.) in methanol, was added slowly a methanolic solution of ammonia (50 ml), and the reaction mixture was stirred at room temperature for 2 hr. The pale yellow colored solid separated out was filtered, dried under vacuum to give 4-nitro-2,3-dihydro-1H-isoindol-l-one (compound 3, 3.570 gm, 81%).

1. customThe pale yellow colored solid separated out
2. filtrationwas filtered
3. customdried under vacuum