4-bromo-3-hydroxy-3-(6-hydroxy-1,3-benzodioxol-5-yl)-1-pentyl-1,3-dihydro-2H-indol-2-one → 5-fluoro-3-(6-hydroxy-1,3-benzodioxol-5-yl)-1-{[5-(trifluoromethyl)-2-furyl]methyl}-1,3-dihydro-2H-indol-2-one

HRID 107054Notes

Reaction equation

HRID 107054 reaction equation
[Br:1][c:2]1[cH:3][cH:4][cH:5][c:6]2[c:7]1[C:8]([OH:9])([c:10]1[c:11]([OH:12])[cH:13][c:14]3[c:18]([cH:19]1)[O:17][CH2:16][O:15]3)[C:20](=[O:21])[N:22]2[CH2:23][CH2:24][CH2:25][CH2:26][CH3:27].[F:28][c:29]1[cH:30][c:31]2[c:35]([cH:36][cH:37]1)[N:34]([CH2:38][c:39]1[o:40][c:41]([C:44]([F:45])([F:46])[F:47])[cH:42][cH:43]1)[C:33](=[O:48])[C:32]2([c:49]1[cH:50][c:51]2[c:52]([cH:56][c:57]1[OH:58])[O:53][CH2:54][O:55]2)[OH:59]>>[F:28][c:29]1[cH:30][c:31]2[c:35]([cH:36][cH:37]1)[N:34]([CH2:38][c:39]1[o:40][c:41]([C:44]([F:45])([F:46])[F:47])[cH:42][cH:43]1)[C:33](=[O:48])[CH:32]2[c:49]1[cH:50][c:51]2[c:52]([cH:56][c:57]1[OH:58])[O:53][CH2:54][O:55]2

Participants

3

Reactant 2

HCID 120044004-bromo-3-hydroxy-3-(6-hydroxy-1,3-benzodioxol-5-yl)-1-pentyl-1,3-dihydro-2H-indol-2-oneHCID 588725415-fluoro-3-hydroxy-3-(6-hydroxy-1,3-benzodioxol-5-yl)-1-{[5-(trifluoromethyl)-2-furyl]methyl}-1,3-dihydro-2H-indol-2-one

Product 1

HCID 588725305-fluoro-3-(6-hydroxy-1,3-benzodioxol-5-yl)-1-{[5-(trifluoromethyl)-2-furyl]methyl}-1,3-dihydro-2H-indol-2-one

Sources & evidence

ORD record
ord-24a0d93b25b14bbb883ea641e361850a
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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