3-(1-benzyl-1,2,5,6-tetrahydropyridine-3-yl)-1H-indole → 3-(Piperidin-3-YL)-1H-indole

Participants

Reaction Steps

A mixture of the 3-(1-benzyl-1,2,5,6-tetrahydropyridin-3-yl)-1H-indole obtained in Example 28 and 10% palladium on carbon in a mixture of formic acid and methanol is stirred at room temperature for 3 days and filtered through celite. The celite is washed with methanol. The filtrates are combined and concentrated in vacuo to afford the title product, identified by HPLC and mass spectral analyses.

Provenance & Evidence