Diethyl 2-(((4-Chlorobenzyl)amino)carbonyl)malonate → HCID 178522945、化合物

HRID 1070603ノート

反応式

HRID 1070603 の反応式
[O:1]1[CH2:6][CH2:5][CH2:4][CH2:3][CH:2]1[O:7][CH2:8][C:9]#[C:10][C:11]1[CH:12]=[CH:13][C:14]([NH2:17])=[N:15][CH:16]=1.[Cl:18][C:19]1[CH:39]=[CH:38][C:22]([CH2:23][NH:24][C:25]([CH:27]([C:33](OCC)=[O:34])[C:28](OCC)=[O:29])=[O:26])=[CH:21][CH:20]=1>C1(C)C(C)=CC=CC=1>[Cl:18][C:19]1[CH:39]=[CH:38][C:22]([CH2:23][NH:24][C:25]([C:27]2[C:28](=[O:29])[N:17]=[C:14]3[CH:13]=[CH:12][C:11]([C:10]#[C:9][CH2:8][O:7][CH:2]4[CH2:3][CH2:4][CH2:5][CH2:6][O:1]4)=[CH:16][N:15]3[C:33]=2[OH:34])=[O:26])=[CH:21][CH:20]=1

参加物

4

反応物 2

HCID 22397146Diethyl 2-(((4-Chlorobenzyl)amino)carbonyl)malonateHCID 223972415-(3-(Tetrahydro-2H-pyran-2-yloxy)-1-propynyl)-2-pyridinylamine

生成物 1

HCID 178522945HCID 178522945、化合物

試薬・触媒・溶媒 1

HCID 7237O-Xylene溶媒

実験手順

5-(3-(Tetrahydro-2H-pyran-2-yloxy)-1-propynyl)-2-pyridinylamine (Preparation 6, 30 mg) and diethyl 2-(((4-chlorobenzyl)amino)carbonyl)malonate (Preparation 5, 50 mg) are dissolved in xylene and heated to reflux for 3 h. The solvent is evaporated and the residue is crystallized from ether/hexanes and dried to afford 20 mg of the a brown solid. Physical characteristics: MS (ESI+) m/z 470 (M+H)+. 1H NMR (CDCl3) δ9.80, 9.12, 7.80, 7.52, 7.32, 7.27, 4.86, 4.65, 4.51, 3.90, 3.5-3.6, 1.55-1.9.

後処理

  1. temperatureheated
  2. temperatureto reflux for 3 h
  3. customThe solvent is evaporated
  4. customthe residue is crystallized from ether/hexanes
  5. customdried
  6. customto afford 20 mg of the a brown solid

出典と根拠

ORDレコード
ord-14c277a041af46518365ce85bfc508c8
出典データセット
uspto-grants-2005_06
特許番号
US06903097B2

反応ノート

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