6,7-Dimethoxyisoquinolin-1(2H)-one → HCID 22397411, compound

HRID 1070674Notes

Reaction equation

HRID 1070674 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[O:13][CH3:14])[C:9](=O)[NH:8][CH:7]=[CH:6]2.[N+:16]([O-])([OH:18])=[O:17].OS(O)(=O)=O>S(=O)(=O)(O)O>[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[C:11]([N+:16]([O-:18])=[O:17])[C:12]=1[O:13][CH3:14])[CH:9]=[N:8][CH:7]=[CH:6]2

Participants

4

Reactant 2

HCID 33124896,7-Dimethoxyisoquinolin-1(2H)-oneHCID 71777668Sulfuric acid, mixt. with nitric acid

Product 1

HCID 22397411HCID 22397411, compound

Reagents, catalysts & solvents 1

HCID 1118Sulfuric AcidSolvent

Procedure

To a solution of 6,7-Dimethoxy-isoquinolinone (2.88 g) in sulphuric acid (20 ml) at 5-10° C. was added 2 M HNO3—H2SO4-solution (8 ml) and the reaction mixture stirred overnight at ambient temperature. The reaction mixture was poured into ice water, pH adjusted to 12 and the product extracted in methylene chloride. The methylene chloride phase was extracted with 1 M HCl , the pH of the aqueous phase adjusted to 12 and extracted into methylene chloride, dried and evaporated. Yield: 2.5 g.

Workup

  1. extractionthe product extracted in methylene chloride
  2. extractionThe methylene chloride phase was extracted with 1 M HCl
  3. extractionextracted into methylene chloride
  4. customdried
  5. customevaporated

Sources & evidence

ORD record
ord-cafc8ce6b4814715810a347df7f9f146
Source dataset
uspto-grants-2005_06
Patent number
US06903114B2

Reaction notes

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