2-Chloromethyl tetrahydrofuran → 4-(3-Methanesulfonyl-phenyl)-1-(tetrahydrofuran-2-ylmethyl)-piperidine

HRID 1070720Notes

Reaction equation

HRID 1070720 reaction equation
[CH3:1][S:2]([C:5]1[CH:6]=[C:7]([CH:11]2[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]2)[CH:8]=[CH:9][CH:10]=1)(=[O:4])=[O:3].[CH2:17](Cl)[CH:18]1[O:22][CH2:21][CH2:20][CH2:19]1>>[CH3:1][S:2]([C:5]1[CH:6]=[C:7]([CH:11]2[CH2:16][CH2:15][N:14]([CH2:17][CH:18]3[CH2:19][CH2:20][CH2:21][O:22]3)[CH2:13][CH2:12]2)[CH:8]=[CH:9][CH:10]=1)(=[O:4])=[O:3]

Participants

3

Reactant 2

HCID 181502-Chloromethyl tetrahydrofuranHCID 129889574-(3-(Methylsulfonyl)phenyl)piperidine

Product 1

HCID 223978454-(3-Methanesulfonyl-phenyl)-1-(tetrahydrofuran-2-ylmethyl)-piperidine

Procedure

Beginning with 4-(3-methanesulfonyl-phenyl)-piperidine and tetrahydrofurfuryl chloride, the titled compound was recovered by the procedure described in Example 1. MS m/z (relative intensity, 70 eV) 323 (M+, 1), 252 (bp), 129 (9), 115 (6), 70 (17). Rf=0.3 (MeOH, 0.03 (EtOAc).

Workup

  1. customthe titled compound was recovered by the procedure

Sources & evidence

ORD record
ord-2a25083d85ba4131a430f63ce391c56e
Source dataset
uspto-grants-2005_06
Patent number
US06903120B2

Reaction notes

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