HuagongsheHuagongshe Chemistry Print Report · For research reference only
Piperazine → 1-(3-(Methylsulfonyl)phenyl)piperazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Piperazine | HCID 4837 | — |
| Reactant | Benzene, 1-bromo-3-(methylsulfonyl)- | HCID 2757146 | — |
| Reactant | Sodium t-butoxide | HCID 23676156 | — |
| Catalyst | Bis(dibenzylideneacetone)palladium | HCID 9811564 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 1-(3-(Methylsulfonyl)phenyl)piperazine | HCID 12988954 | — |
Reaction Steps
A mixture of 1-bromo-3-methanesulfonyl-benzene (0.8 g), piperazine (1 g), sodium tert-butoxide (0.5 g) BINAP (42 mg) and [Pd2(dba)3 (38 mg) in toluene (7 ml) was heated under argon at 80° C. for 24 h. After cooling to room temperature, the solvent was evaporated to dryness. The crude material was purified by flash chromatography on silica gel using EtOAc. Yield 0.48 g: MS m/z (rel. intensity, 70 eV) 240 (M+, 17), 199 (12), 198 (bp), 119 (9), 56 (7).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06903120B2 |
| Source dataset | uspto-grants-2005_06 |
| ORD ID | ord-12fce80713fe436d83fad2907efde3e6 |
| Source note | uspto-grants-2005_06 |