Phthalimide → HCID 102328870, compound

Participants

Reaction Steps

The reaction of the phthalimide to the amine occurs analogously to Example 21)d): 23.3 g (48 mmol) 2-(4-{4-[bis-(4-fluorophenyl)-methyl]-piperazin-1-yl}-but-2-inyl)-isoindolin-1,3-dione and 4.7 ml (96 mmol) hydrazine.hydrate. The purification occurs by chromatography on silica gel with CHCl3/CH3OH (90/10 to 85/15): Yield 9.8 g (58%).

Provenance & Evidence