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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1070810Generated: October 26, 2026

trans-2-Phenylcyclopropyl isocyanate → 4-{2-[4-amino-2-(ethoxymethyl)-6,7-dimethyl-1H-imidazo[4,5-c]pyridin-1-yl]ethyl}-N-[(1R*,2S*)-2-phenylcyclopropyl]piperidine-1-carboxamide

https://huagongshe.com/reaction/1070810

Reaction equation

Participants

RoleNameHCIDCharge
Reactanttrans-2-Phenylcyclopropyl isocyanateHCID 255285—
Reactant2-(ethoxymethyl)-6,7-dimethyl-1-(2-piperidin-4-ylethyl)-1H-imidazo[4,5-c]pyridin-4-amineHCID 12972962—
Product4-{2-[4-amino-2-(ethoxymethyl)-6,7-dimethyl-1H-imidazo[4,5-c]pyridin-1-yl]ethyl}-N-[(1R*,2S*)-2-phenylcyclopropyl]piperidine-1-carboxamideHCID 20575808—

Reaction Steps

Using the method of Examples 54-65, trans-2-phenylcyclopropyl isocyanate was reacted with 2-(ethoxymethyl)-6,7-dimethyl-1-(2-piperidin-4-ylethyl)-1H-imidazo[4,5-c]pyridin-4-amine to provide the desired compound. The observed accurate mass was 491.3139.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06903113B2
Source datasetuspto-grants-2005_06
ORD IDord-0b8dd068d3d943c694d50443deca656a
Source noteuspto-grants-2005_06