Carbamic chloride, N-methyl-N-phenyl- → N'-{4-[4-amino-2-(ethoxymethyl)-7-methyl-1H-imidazo[4,5-c]pyridin-1-yl]butyl}-N-methyl-N-phenylurea

HRID 1070829Notes

Reaction equation

HRID 1070829 reaction equation
[CH3:1][N:2]([C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)[C:3](Cl)=[O:4].[NH2:12][CH2:13][CH2:14][CH2:15][CH2:16][N:17]1[C:25]2[C:24]([CH3:26])=[CH:23][N:22]=[C:21]([NH2:27])[C:20]=2[N:19]=[C:18]1[CH2:28][O:29][CH2:30][CH3:31]>>[NH2:27][C:21]1[C:20]2[N:19]=[C:18]([CH2:28][O:29][CH2:30][CH3:31])[N:17]([CH2:16][CH2:15][CH2:14][CH2:13][NH:12][C:3](=[O:4])[N:2]([CH3:1])[C:6]3[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=3)[C:25]=2[C:24]([CH3:26])=[CH:23][N:22]=1

Participants

3

Reactant 2

HCID 77969Carbamic chloride, N-methyl-N-phenyl-HCID 219460261-(4-aminobutyl)-2-(ethoxymethyl)-7-methyl-1H-imidazo[4,5-c]pyridin-4-amine

Product 1

HCID 22397371N'-{4-[4-amino-2-(ethoxymethyl)-7-methyl-1H-imidazo[4,5-c]pyridin-1-yl]butyl}-N-methyl-N-phenylurea

Procedure

Using the method of Examples 147-164, N-methyl-N-phenylcarbamoyl chloride was reacted with 1-(4-aminobutyl)-2-(ethoxymethyl)-7-methyl-1H-imidazo[4,5-c]pyridin-4-amine to provide the desired compound. The observed accurate mass was 411.2532.

Sources & evidence

ORD record
ord-e8b023be83444c9bb3008f7c8e06d466
Source dataset
uspto-grants-2005_06
Patent number
US06903113B2

Reaction notes

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