HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyridine → HCID 22398289, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | Acetyl chloride | HCID 6367 | — |
| Reactant | 3-Methylisothiazol-5-ylamine hydrochloride | HCID 2723918 | — |
| Product | HCID 22398289 | HCID 22398289 | — |
Reaction Steps
Compounds 179 and 189 were synthesized as shown Scheme 7. Reaction of 5-amino-3-methylisothiazole hydrochloride with acetic chloride in pyridine followed by nitration and reduction gave an intermediate of 4-amino-5-acetamido-3-methylisothiazole. Reaction of the intermediate (1.2 eq ) with DBD under N2 afforded Compound179. Refluxing 4-nitro-5-acetamido-3-methylisothiazole in 4N HCl aq. and further reacting with DBD under N2 with refluxing yielded Compound 189.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06903133B2 |
| Source dataset | uspto-grants-2005_06 |
| ORD ID | ord-1472b606c43d42c2972cad841c077d5b |
| Source note | uspto-grants-2005_06 |